	   SnapGene      !Çaccgtattaccgcctttgagtgagctgataccgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgaggaagcggaagagcgcccaatacgcaaaccgcctctccccgcgcgttggccgattcattaatgcagctggcacgacaggtttcccgactggaaagcgggcagtgagcgcaacgcaattaatgtgagttagctcactcattaggcaccccaggctttacactttatgcttccggctcgtatgttgtgtggaattgtgagcggataacaatttcacacaggaaacagctatgacatgattacgaattcgagctcggtacccggggatcctctagagtcgacgctcgcgcgacttggtttgccattctttagcgcgcgtcgcgtcacacagcttggccacaatgtggtttttgtcaaacgaagattctatgacgtgtttaaagtttaggtcgagtaaagcgcaaatcttttttaaccctagaaagatagtctgcgtaaaattgacgcatgcattcttgaaatattgctctctctttctaaatagcgcgaatccgtcgctgtgcatttaggacatctcagtcgccgcttggagctcccgtgaggcgtgcttgtcaatgcggtaagtgtcactgattttgaactataacgaccgcgtgagtcaaaatgacgcatgattatcttttacgtgacttttaagatttaactcatacgataattatattgttatttcatgttctacttacgtgataacttattatatatatattttcttgttatagatatcgtgactaatatataataaaatgggtagttctttagacgatgagcatatcctctctgctcttctgcaaagcgatgacgagcttgttggtgaggattctgacagtgaaatatcagatcacgtaagtgaagatgacgtccagagcgatacagaagaagcgtttatagatgaggtacatgaagtgcagccaacgtcaagcggtagtgaaatattagacgaacaaaatgttattgaacaaccaggttcttcattggcttctaacagaatcttgaccttgccacagaggactattagaggtaagaataaacattgttggtcaacttcaaagtccacgaggcgtagccgagtctctgcactgaacattgtcagatccgagatcggccggcctaggcgcgccgtacgcgtatcgataagctttaagatacattgatgagtttggacaaaccacaactagaatgcagtgaaaaaaatgctttatttgtgaaatttgtgatgctattgctttatttgtaaccattataagctgcaataaacaagttaacaacaacaattgcattcattttatgtttcaggttcagggggaggtgtgggaggttttttaaagcaagtaaaacctctacaaatgtggtatggctgattatgatctagagtcgcggccgctacaggaacaggtggtggcggccctcggtgcgctcgtactgctccacgatggtgtagtcctcgttgtgggaggtgatgtccagcttggagtccacgtagtagtagccgggcagctgcacgggcttcttggccatgtagatggacttgaactccaccaggtagtggccgccgtccttcagcttcagggccttgtggatctcgcccttcagcacgccgtcgcgggggtacaggcgctcggtggaggcctcccagcccatggtcttcttctgcattacggggccgtcggaggggaagttcacgccgatgaacttcaccttgtagatgaagcagccgtcctgcagggaggagtcctgggtcacggtcaccacgccgccgtcctcgaagttcatcacgcgctcccacttgaagccctcggggaaggacagcttcttgtagtcggggatgtcggcggggtgcttcacgtacaccttggagccgtactggaactggggggacaggatgtcccaggcgaagggcagggggccgcccttggtcaccttcagcttcacggtgttgtggccctcgtaggggcggccctcgccctcgccctcgatctcgaactcgtggccgttcacggtgccctccatgcgcaccttgaagcgcatgaactccttgatgacgttcttggaggagcgcaccatctcgaggtcacttggttgttcacgatcttgtcgccgccagtgtcaacttgcaactgaaacaatatccaacatgaacgtcaatttatactgccctaatggcgaacacgataacaatatttcttttattatgccctctaaaaccaacgcggttatcgtttatttattcaaattagatatagaacatccgccgacatacaatgttaatgcaaaaacgcgtttggtgagcggatacgaaaacagtcggccgataaacattaatctgaggtcgataacaccgtccttgaacggaacacgaggagcgtacgtgatcagctgcattcgcgcgccgcgcctttatcgagatttatttgcatacaacaagtacactgcgccgttgggatttgtggtaacgcgcacacatgcagagctgcaagtgtggcacattttgtctgtgcgcaaaacctttgaagccaaaagtacgaggtccgttacgggcatgctagcgcacacggacaatggacccgacaaattctacgccaaggatttaatgataatgtcgggcaacgtatccgttcattttatcaataacctacaaaaatgtcgcgcgcatcacaaagacatcgacgcgcgtagaattctacccgtaaagcgagtttagttatgagccatgtgcaaaacatgacatcagcttttatttttataacaaatgacatcatttcttgattgtgttttacacgtagaattctactcgtaaagcgagttcagttttgaaaaacaaatgacatcatctttttgattgtgctttacaagtagaattctacccgtaaatcaagttcggttttgaaaaacaaatgagtcatattgtatgatatcatattgcaaaacaaatgactcatcaatcgatcgtgcgttacacgtagaattctactcgtaaagcgagtttatgagccgtgtgcaaaacatgacatcatctcgatttgaaaaacaaatgacatcatccactgatcgtgcgttacaagtagaattctactcgtaaagccagttcggttatgagccgtgtgcaaaacatgacatcagcttatgactcatacttgattgtgttttacgcggtttaaacgcgcccatactcggtggcctccccaccaccaacttttttgcactgcaaaaaaacacgcttttgcacgcgggcccatacatagtacaaactctacgtttcgtagactattttacataaatagtctacaccgttgtatacgctccaaatacactaccacacattgaacctttttgcagtgcaaaaaagtacgtgtcggcagtcacgtaggccggccttatcgggtcgcgtcctgtcacgtacgaatcacattatcggaccggacgagtgttgtcttatcgtgacaggacgccagcttcctgtgttgctaaccgcagccggacgcaactccttatcggaacaggacgcgcctccatatcagccgcgcgttatctcatgcgcgtgaccggacacgaggcgcccgtcccgcttatcgcgcctataaatacagcccgcaacgatctggtaaacacagttgaacagcatctgttacagcgacacaacatgagccggtccaacaacgccaacgcgcccacgccatccaaccgccgccgcaacctgtctctggtgttaattaaatgaccgagtacaagcccacggtgcgcctcgccacccgcgacgacgtccccagggccgtacgcaccctcgccgccgcgttcgccgactaccccgccacgcgccacaccgtcgatccggaccgccacatcgagcgggtcaccgagctgcaagaactcttcctcacgcgcgtcgggctcgacatcggcaaggtgtgggtcgcggacgacggcgccgcggtggcggtctggaccacgccggagagcgtcgaagcgggggcggtgttcgccgagatcggcccgcgcatggccgagttgagcggttcccggctggccgcgcagcaacagatggaaggcctcctggcgccgcaccggcccaaggagcccgcgtggttcctggccaccgtcggcgtctcgcccgaccaccagggcaagggtctgggcagcgccgtcgtgctccccggagtggaggcggccgagcgcgccggggtgcccgccttcctggagacctccgcgccccgcaacctccccttctacgagcggctcggcttcaccgtcaccgccgacgtcgaggtgcccgaaggaccgcgcacctggtgcatgacccgcaagcccggtgcctgagagatcttcgacctcgaaacttgtttattgcagcttataatggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttatcatgtctggatcatgtcgagggggggcccgatttaaataaaccccgggcgagctcgaattaaccattgtgggaaccgtgcgatcaaacaaacgcgagataccggaagtactgaaaaacagtcgctccaggccagtgggaacatcgatgttttgttttgacggaccccttactctcgtctcatataaaccgaagccagctaagatggtatacttattatcatcttgtgatgaggatgcttctatcaacgaaagtaccggtaaaccgcaaatggttatgtattataatcaaactaaaggcggagtggacacgctagaccaaatgtgttctgtgatgacctgcagtaggaagacgaataggtggcctatggcattattgtacggaatgataaacattgcctgcataaattcttttattatatacagccataatgtcagtagcaagggagaaaaggttcaaagtcgcaaaaaatttatgagaaacctttacatgagcctgacgtcatcgtttatgcgtaagcgtttagaagctcctactttgaagagatatttgcgcgataatatctctaatattttgccaaatgaagtgcctggtacatcagatgacagtactgaagagccagtaatgaaaaaacgtacttactgtacttactgcccctctaaaataaggcgaaaggcaaatgcatcgtgcaaaaaatgcaaaaaagttatttgtcgagagcataatattgatatgtgccaaagttgtttctgactgactaataagtataatttgtttctattatgtataagttaagctaattacttattttataatacaacatgactgtttttaaagtacaaaataagtttatttttgtaaaagagagaatgtttaaaagttttgttactttatagaagaaattttgagtttttgtttttttttaataaataaataaacataaataaattgtttgttgaatttattattagtatgtaagtgtaaatataataaaacttaatatctattcaaattaataaataaacctcgatatacagaccgataaaacacatgcgtcaattttacgcatgattatctttaacgtacgtcacaatatgattatctttctagggttaaataatagtttctaatttttttattattcagcctgctgtcgtgaataccgtatatctcaacgctgtctgtgagattgtcgtattctagcctttttagtttttcgctcatcgacttgatattgtccgacacattttcgtcgatttgcgttttgatcaaagacttgagcagagacacgttaatcaactgttcaaattgatccatattaacgatatcaacccgatgcgtatatggtgcgtaaaatatattttttaaccctcttatactttgcactctgcgttaatacgcgttcgtgtacagacgtaatcatgttttcttttttggataaaactcctactgagtttgacctcatattagaccctcacaagttgcaaaacgtggcattttttaccaatgaagaatttaaagttattttaaaaaatttcatcacagatttaaagaagaaccaaaaattaaattatttcaacagtttaatcgaccagttaatcaacgtgtacacagacgcgtcggcaaaaaacacgcagcccgacgtgttggctaaaattattaaatcaacttgtgttatagtcacggatttgccgtccaacgtgttcctcaaaaagttgaagaccaacaagtttacggacactattaattatttgattttgccccacttcattttgtgggatcacaattttgttatatttttaaacaaagcttggcactggccgtcgttttacaacgtcgtgactgggaaaaccctggcgttacccaacttaatcgccttgcagcacatccccctttcgccagctggcgtaatagcgaagaggcccgcaccgatcgcccttcccaacagttgcgcagcctgaatggcgaatggcgcctgatgcggtattttctccttacgcatctgtgcggtatttcacaccgcatatggtgcactctcagtacaatctgctctgatgccgcatagttaagccagccccgacacccgccaacacccgctgacgcgccctgacgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgtctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacgcgcgagacgaaagggcctcgtgatacgcctatttttataggttaatgtcatgataataatggtttcttagacgtcaggtggcacttttcggggaaatgtgcgcggaacccctatttgtttatttttctaaatacattcaaatatgtatccgctcatgagacaataaccctgataaatgcttcaataatattgaaaaaggaagagtatgagtattcaacatttccgtgtcgcccttattcccttttttgcggcattttgccttcctgtttttgctcacccagaaacgctggtgaaagtaaaagatgctgaagatcagttgggtgcacgagtgggttacatcgaactggatctcaacagcggtaagatccttgagagttttcgccccgaagaacgttttccaatgatgagcacttttaaagttctgctatgtggcgcggtattatcccgtattgacgccgggcaagagcaactcggtcgccgcatacactattctcagaatgacttggttgagtactcaccagtcacagaaaagcatcttacggatggcatgacagtaagagaattatgcagtgctgccataaccatgagtgataacactgcggccaacttacttctgacaacgatcggaggaccgaaggagctaaccgcttttttgcacaacatgggggatcatgtaactcgccttgatcgttgggaaccggagctgaatgaagccataccaaacgacgagcgtgacaccacgatgcctgtagcaatggcaacaacgttgcgcaaactattaactggcgaactacttactctagcttcccggcaacaattaatagactggatggaggcggataaagttgcaggaccacttctgcgctcggcccttccggctggctggtttattgctgataaatctggagccggtgagcgtgggtctcgcggtatcattgcagcactggggccagatggtaagccctcccgtatcgtagttatctacacgacggggagtcaggcaactatggatgaacgaaatagacagatcgctgagataggtgcctcactgattaagcattggtaactgtcagaccaagtttactcatatatactttagattgatttaaaacttcatttttaatttaaaaggatctaggtgaagatcctttttgataatctcatgaccaaaatcccttaacgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaaggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaaacaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagagctaccaactctttttccgaaggtaactggcttcagcagagcgcagataccaaatactgttcttctagtgtagccgtagttaggccaccacttcaagaactctgtagcaccgcctacatacctcgctctgctaatcctgttaccagtggctgctgccagtggcgataagtcgtgtcttaccgggttggactcaagacgatagttaccggataaggcgcagcggtcgggctgaacggggggttcgtgcacacagcccagcttggagcgaacgacctacaccgaactgagatacctacagcgtgagctatgagaaagcgccacgcttcccgaagggagaaaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgcacgagggagcttccagggggaaacgcctggtatctttatagtcctgtcgggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtcaggggggcggagcctatggaaaaacgccagcaacgcggcctttttacggttcctggccttttgctggccttttgctcacatgttctttcctgcgttatcccctgattctgtggata  I�   $                                               )            1   &   #      "       (      "   !   "         "   %                          $   6      )   "         '      (   <      -   "            $      7   $   #   (                     #            +      .      %   $      "   %   #   +   T   >   6   -   4   (      &   :   &         :   "         ;   ,           ,   ?         (   "         %   #   /   '   3   ,   $   !      &      )                      '   +   +   *   *   (      +          0                        >   -         &   >   $      +            +   3   #      1   K   %   6   H   w   #      (   0               #      $   $   (          &                               "              #   )      &   ;   (      C            +      >      2   $      "   #   '   #      $              #               *      ,   &   '               !   %   1                     &   #   %                 $ O[\Š‹ÁÍKco•–—³´äÃÄ–¿ÀÁÂ Þßø%\ ] ^ !!S!T!U! P]fñÎLd˜Í	ñ3ešÞ¡àû&½ ÷ ! 2ŒpyM‰b—ÿ…‘Þ' _ ß #! ¬ %fÂ®µå-
o
âüsÅ\hÃÙéSùS V!  Y^gò�Ê„GJ}	´,~ƒ§Öf¸Ã†Ï'w ¾ ê ø Z! L R ¥ %²ÏM�t	ëò4'ß¢®üä !c! Qwoež8	Î	]
³“E>› cá‚Œ7±iA Á! E6Ï:Q™?
F
› ¹Úñ<�ªöLÛq»™, È   ra¸»ÈàõšqÒ1	ª¼Ü„ŸÉ˜ìë•“g†ÕV¸Z Hw3ÅáAŒK�Ö	Vx¬ùh‚­úçl‡Í Ô ! ™ p¢Ujcé…V•ñ7IŽºn .nƒ’?»]( ` $!�! ÌT¯À[]	#
z…NŠ¥cßO à  fiŸ¾“l¨æ·&—¢ÆH†ÚÓEéU\õW‰ G Å W! � ­ Ù ¯ö	.
p
`]iL~ÿ¾ù–@g;p.Û  â ÷ ‘&tøÍÒê³·Ž T ) { —•™¨Á.Qg Ã¶Úé
H	­ãlpýÙäü%>‰Ä,Ä*TŸªúÄv!ˆ!“! J duÃ4?g_hóžËHY[	{	!
$„ê½‘(,¹‡õ  �¨	µÓ¨ 
g†Èu	K­Jã¹tP� ¦ ¿ ë   > Ç [ÐœrÉ¡Ë
6–ê¤Îè×4U�»C�(æ1  5 F V ³ BZEi§…K4	~	é	×
ò\€IU·í-�ÉÝ•w¨ÜÄÐØöp˜x Ÿ í ù 8![!& M S °™±´ÌÐñ*BN«)
¾ói·Åð)Žº_%zÈÀ»„º # ¦ &í„çèü�>	B‹/£iˆH,àAO£_jU?¨ Á !d! <0!Fß¹
$mØ>Žã(g/‘QX6v" - Šó³@ß�2žº	p	u	@ìc^ó5½¯›ËýZ;ÒX | Š å   BcœÀÆÝø7ÜîfŸ;<uŽ”öàc¯tÙd,ƒÿ8H!(  ñÓö«²¾À	9	L	a	f
¤,ÊÕƒ®ºxÕF\zñ”�ÆRÈŸ 7 B ‘ Â!  6³„­Åx•ª	Ï	^
[†É×òM�²?ƒa‘•?!¹!" R�Š‘›pümˆ	Æ,Q7Õ"´üœÈœ4}¡²´âôI²¾j! `»¦?fŸð>¯
¡ºÛòïò‘”äI›.÷ÜæLŒ
"4 " • 1F~ÐRš	@
L
©
é
MnµvyÜ‚¯rÈål®$EÉ  ¡ k¼7;º{™�ás£Ú:~- 3! 1 ”(G
œÊ=«Tª÷
)Måù¶[gßb¼šwÓþ€ "  dŠ¹¼ïOm›ØÔ	ô	«‡ 5�Œï1Ù|˜”�óÜ[  ¿!%  D ± Å bšºôs‚—åæúö2	†	³Œô-IØZh’"Ö¹ä� F! ¾|báÓ}ò	÷aŠ[¦È½…Êí|'î1N&'µ   <iÏÉr
Þ
_Êù0cMÝu™íøóXˆì~–¨‡€We  4âlã4Lë]á¶
!jÕ;i^3·½Ù  Òûx“By×	Ä
/xãIW­¬x~ð1n®pèm1ˆÕ   ü ­�v
 "£yÀ¦ºt6Tåiƒ×ûèÎ ! IÆ§ÑŽ{Š‚	¾	
ïWŠÐ§#ú	$-îä)ð¡E x  oQìÕdÊ	¨Ê`ê‰�dr\E‚@øD“) $ É ßü2ê	(
Ò
Î4W
n¿J»kÀ´šä3¨ìºo“Àü; ¯!6 š q£ÀÇ¹ËOkð-	Í
=†ìŒ–ü6�?D¤²“¯åù6<`e—9W×kË/„»P½Ï¼}è^b%! é7VÓ-Ag|
8�RÌò8ïo¿#Péî¬a ‚!£!) ]†Í6O£…Ç`isE	^	l
˜
]{4p‹»Erçº#vr*Q�üÈÕ)  P á  !<!" @ ‹©o~žÚU†Á\¢˜d…OÛZžÈè9(8u�O*súO! õt° 
«¶¦Kd¯[Eïà  ¢aæûXú	$¢j	$
€-†õ“~G!' P ª uß¦¿ˆmçç6	“àKŽ�£ÁÇï‡ËÔf€¬>«ø�ŠåXM Æ Ù X!t! < H i.a©©¸É
4ètíÛúÓF#VHX z ( v „‰ùg˜·j«+	€	´
Ì2~n¹3Iª°Æ•ãî!úê Úø/› :!­!< 7 X t µ g€‚×, ¢Ë”6 ,M–	˜	�	Å	Ü	
7
›
�
²
žõ'9–ß*l˜Þ m�‘±ûÑH]ßFªöG¤-šH ¬ ï  ' 9 Š ® Ñãôÿ°æ	JaÔj=þªJ}–ð•œJ Ü - c · ¼ Ù\'u‡#	î	
q
à
¯ûeÊOÞL¯Z€^¸V´ayMZcu 6<Iq/?o!" 
>©GBº.�	³	/
Ÿ
hà\s�:SyÓx�µú"A&Zhg ‘ Ú z!~"OÞ	÷	9
ÅÜ ý¿/˜—‰ÞÕóÜg ñ   � 9$’�	ë	Wù'BÙdw‚´¸ÃM8 	 U �! ,¬3
ÍpáÅîÆQró¡ $ ã ñ “Ukk·ñ '`VtËð
auÖÁ2Ó@—ºë øÍi;�s ³ û    Í ø Dc\TÍÖ–8(uwÎß&ºlªóÝV¦îK!›!7 $ * | Ro–¤©RU‚ÄÙ÷!‡·v	I	š	Ç	ô^m×‚©¬þš±ÐåýoŠ“áDÅ²#Òfº$ u˜Ô./y
X
Ù
N½�žæ%,A?-lRéŠ¿Ï… ûÅ ® *!k!#  j šh¡Ÿ	®q÷;áŸ6—õ#\üM_UaHï/Yá!]!w!‰!”!( Z Âv©EºÛêðö¯× ä)H˜ÖÚ&/P›³ïÅ6‰+8Ãá,Ã«n  ZeÌ­²ãû[a¾dþR¼ Þ ö !R! K $Dv5±P�I|	\
¸ð+õ’ºÂ˜°é  ˜ ËÄ
@T`i·ôJZ\	"
ƒëm-m’U·†Ì  Ø á ehž’Ÿ§k%…+ÒDK)ˆ-ÃF Ä  U Z¦3> è	¶Çv
¬'+ºso—ì  ì°³ EÞ	¸
#l×=]h‡¶(+�¹¼^Ê5TuÑ§ À # ²ðÄŒ›¿‰�½6í	©	Ô
!tÉL±s|±þHQ�½ž�  >ï¨
©äµ¢®-föaK‹ä}Dvý3   C ° {�–ÎäåN|ñ	L¥€0Øò{Ž‘´   Ñx½	
i:îVÏ¦ ]¥ís mDo+ È Æ6Ê1Ò,Ì
Ñ
7<€ëQ_éˆj�¿ø5dVq™Öã[jD¹�¼è’|ç¿:  ? \ôN�`s¢å_D	—c"u8N) !. 6 ; G O W © ´ Ö+`¨¶Þ+L5		6
È
3çsJ¸ÀîlŽÊ¯"ªÙ÷W™L y š « Ø î 9! Ft}ógU[r`x©ÝY5òf”Ûn!%  Œ Ì +C’[j¶#ÿ_UÊŒ	ê	ï
tÀV?Þo¹Ä¹Åhqr   ú $ ) Ón¨öD†
Ø
óM]ÖG�Õ.kQ–"[L¾ÂÑ¹m \! O¬[
‚*`ôÑclCJQ
Á¯…E » Ã " T ±ïÃš²D¼§
\sÆ*¡�¸»`&r{°Ér¼
nÐ2 % Åz•Í_0wÑ+¼	ð	
h9U¥tñiŽ¤¾ì÷zp˜Zilç‘{ # N ¨ Õ_µÝµ"sòC*
Ç
2æLÔ¿Tqj®¸Ã¸½
Xeª × + § ÄÔî^^r
¦
Æ
1åKTSp¤ÐksIh�ë —·Y·P	kqæW�®	© Â T ý¡-÷éêëì{Þ%	&	?	


’
“
â
CDŒ�±ýgÌÍÎÏQRSj{|}>\]^efgò‰½òIw¢£¤ÂÃWXápVš­×EFGHe!f!> Ûþ'¢.…èøíý†üO
”
Iz’¶-AÆOclÎ¶é>~ì?O_ó-IMW[€›£Ãó¥ÄÉ'¤ÇÑôÉ@Ø¥6 e '¬JÓ,|Žß'	@	O	
ã
EŽ²þhšÐóY0—Ò d¯Ë/‰ QŠ§¾Jx³âB`K›AI!g!- ‡ Â �r£/ùàî‡´	 	C
c
i
•
J“·ÇF ·ê)WíP`‹RYr€¥õÖ7	84 ^ (#*†éG)’Æˆ
.BPXmÏØá@}¡×ôFJNX�†� ¤í0ô}ÈÒèý zA¦( ¾ 	=ÿÖþ>¥ýP
º
%nÙ?Âdä?ªÈ.\hœËÄ’¦ÅÊ {¢wv¨ Ü1"V	{Â�Ç·3Ûç(ø¥ÊËÙ3ö& . ¹ ­‘×Ÿä(	q	Ù	s
›N�“ !á?ÒyëKÒCaÌ±A<áY } !h!q!: (ôK€-58;´�™»Ã		A	P	d	v	¹	ä
þ
F�³ÿiÑíZd{Š60ÜR¿Óf´AÒ§—Ù>sBæ & ‹ÊùXÚAà‘3‚‰¼ôà_1˜Ì‹»K,óœ£êLS[1oœxŠÓ‹  f æÔ}à
‹
AÐ¥±ºÓèôe°Š¨Û ¾ã°ëŠÉþJ 0�Þ8­µD
âGv¸éSZ“�eÜ9„ 5a!: /4¹¤«Cd�ÁÊÇ™Ýï0<œd
Õ
ç
K”¢¸ðZly~È�÷*„“îßÕðŒxá×Ú8jŽ
9Ñ¤ " Ã þ žçúMˆù2g 	j
–
Ü
¡­¸=¾ëX†¸v7$s¦Õñæ¡! ˆ ï sáïÕ!	ä	1
•¨QaÄád°öu{-I! ò)½	ìY&	6 ·k{BS8 !; �Ô÷(+H³ *ÁM	b	g
‰
ü
?DQnÐbÅ-<UÖA{¢¨¼ÕõGKOUY„‡¡¥»G{~éòþˆ•ŽÇÉ C , Ú$&I‡ê“Ç	›¥ªý`KËÙâ~„‚‘¯î8yÍÖçõ÷a«‘Ó…‡   _ Ï¬¿ª	:	µ	€¤è$/C{MØ±1	]É(‰ §ç’   
 ÜÿNƒÃ?\�¬‡=:ì 3€]N{ÅÀíi’,  „ ¿ Õ 7®×þì;–¼ÒþS	•Ãå�ÂHµÉmp�ØóÏcÆË!$x|ýxPwb? @…Æâ	öÿH¦Éô«	¯	Ð	û	_
€
ö
euÊ€Íän«Ðý/iÌ‡‘ù�“�§³Î@„“£­k…e·¿!C–¢©@! € >x´yDø’	Q
»
&oÚ@ƒ@—VÍ2/º! ’¯í¥	¬
ÃÇ-v˜°è6F|Ö9¡UpÜù5˜µõJ( ‰Ž1‰	…
¡
ì
P|§¿"q�ÿ^�ªµý„�Èþ�¸Ø4¬è)�;~ãêk" ÝI±#œqýTnW	S
Rj#¥‡Û“Ûö:z¦¢\Ë³Ì4! S2K‹•	x
%¡8ÉüÙ³ ¿Ú ÷Ð ²! #¿Ðr	+
=
Ú•J%<oça#Z !% / “ :®’Ñ@gñeÛk¾<	y	
Œ¢"Oð’Ç¡	ÓM‹²* =5 ~ ó # ¼¸ò‘ Øy? „	t
ÓúYgˆóåœ"âæ²/zìLÓ�ÍBâ/ a º a§©€×4å)	Ú	V
°
‘œÔÞ&»ÜóŽ”œ(j¯ßÑ@ø	vÝD_b± 	!i!r!' – ")�®1¯µ�S›B	¶îE]eq O³+¯ÔôB¨RmFk ˜ Ê ç 3 ›õÑØ.69<„�Ä	·	º	A
M
�
¤
ÿ
Gf�´7ñy‹ÒMajÚðëng µÐ£æ¯×?tC, 2GÈL�Áš
		Q	â	ù	ª
å
ê
N  joê;“|Dz71‘üÝSÂ…Ë–ÚåŸ!$ è  Ž}¼e	w	À	à	;
ÑÒ19 [w/ÝÀƒ°òsŠÉÓ*˜%i … ! ¢ �|ÓŒ’Š¬Â	)Ç~*3šâ¼RÁÛ�šTõ^pó‹©Œ  Œ 8Û3Ížu,M\2& ê l½îúY<á>_ƒ‚½2}À&/Ì!Œt¤-Žô™à;¤¨_ž‹�Ë4! Ñ ËB4+»ßE|¦õá`™ULšGëc�yÔ. )     2 g •g	�Ñ¦Ë1>R"BØÞøõf©±·31Œ5>½ÊÿNÞ$ > ‡   ÕGQá¶¹6¬UXéæˆ¿àcK‹'›xÔKTu¢Èÿ )~æÄ$
Œ
B²«»ÿ*ú‹©\é� ” -! Ü KçH
À
té ÔNÜhäïËÕ±ìZÿ 1eð”Ì	ˆgð2™Ý„�ÝúÝ÷ ¤ XÎ9nœƒŽFE
©‚¦²ÚDŸ�…Î6+ v b!À! o¡qS‹ºß®¿b0	Õ	U»6H�w¹øê”‚f>ºk\!' z � –�½-PÙ	¶õ	¬¡ãû=}½ÃèT[•ôf:V¶�  ‡!’!+   E ² Æ c›DtÂÈ3	Z	Ö
•ñ[ì�…”3J§Tâ¸ÛB�×OåõŽ ž ¥ 7!+ ‰ƒ˜Ëæ~çû?ÞðA(1Œ�o	
AŠ?bÄïf.�^Piy:ºW *  5ƒ¬õÅ”š÷:‡	e
Z£+…�õ+‚Öñw›Ç‚b®[yðØ“óÅ`”ÇG!¸!* 0º¥»e}ž'=è
L¹mz´É	Høš˜œàZÙÛå	9k­#Ò2!( Ä Ÿ;ùc‰îl×Ó	ó	
Ý
^øb‰Ç†‹î‹ìó‡H0—}%§òE!¾! â3ê\Ÿ!¢¿",¹w}(ïÖç2¶Ø+ ÿ ¿ÞènûPNÔf	‹§Ém¾Ë5>Cî’®ä;_c¾82O§ºOa«û¢!  ¨n}…úh¡r~ÿ	k
—
\„ªµ’®¹Yq)DP}î't(r ! øtÊÄ	
Ë1Þù©ÐÅ”âíGe©=œF£,¬!0 ‰ 	=[Ðyâ&A ¹þ†"	�	²	å	í	ß
®údÄÉÛINY<€ý9RYbt —!ˆ|Ô•ï>f  ð jSðÕs2
`Ìv–&©ò÷Uví�Â7:ò J!�!š! t-®Öšî5èô5‰Cˆ±G„.Xe  × ÊC�âjýlT¶Â Yë=¾î=ÝŸ5ì 		·
"kÖ<ãµ'eŠ|C� ó5ãäM^Ð
í‡r
c7¸³¾9 ! Ë ~*m5
Z_Z!4g¸Ú yÂ”C´»!r­B£½Âöy¼¯qd D Ö > ÃÓü&,I+qzÝN	Å
0yäJ™@XÅRoÍÑc®Ï.==êHLPVZˆ¢¦¼ñH–¡¶È&²Æóoå�È™¬- † Á Õ")³	U	b
h
ÁEÆV×à| ©ÇÖE…�Ÿ¶2Úæz÷q|ÿy§Ê2õ å�Éø4Âc	Ø	Š
ý
ÏçàÑÿê‰–ÈéRnà‰ î ý .¸LŽ˜ÔÔ
¡ïYx½ƒ§…·uïè’Ôðz4£ `!& ŽÙ %'¼©	û
#>CazÄJL§»Ô%ƒ°7æö5ªj†ˆ!>  Ûáýëþ:õ
ÈÑó÷®	õ
œ«9€ÁGÌãm´Ïülo–UzÎøbœÍ#w~¬j„d¶¾1ü.O¿$ °Jˆ®”ì¤	w
„
¦u—¯çþ5¤©ƒœÚ’Úõ9×ØÿéÏ !±! ` 9·Ðñ¨¾;	ƒ	
*
U
�ù%X‹Æ$Ðånu^`~!+ ç ­ÇÀƒ®�|	¶	¿	�
eÐ6éð0DpÑLN�ûÙï²*ñÏ¢Ê•)ä„ —  íÒ‹«*ÞD�¥T|¿
%).2Ë 
QF§^b€Š¨   J¿
s5¨2‡îSt¡èþ# = “  y n•WpRÍ,‚¾Ea/	Ë	C¼ƒ=ùj* u +  ˆ &Ä>@'9n	
@Y‰„>aëGÃ�2evš¦ÆY]�·Aò“Æ6!3 §mÝmO„øíké[ÖeqÒ	þ	]žˆ ©4Š‘íBŠ!p‘­:^bO|/–¦í¹`D!# s,@…±	­ÃÚHË;4Ïç“sB‡ÿF<FTÓE”Áî=dŽ!™! Ê Ö }ÉB<í<ÿÏ
´qbd‰ŽÁ1 … À ÂäÁÈº3p	T	a
˜ÀÄÌæÁéDŽžßµÐþ• µÇÙå%y±ö»päQxc˜¦«ßK í ¯Øàüÿ»ýôK—¨ÐÓëòö£	­	ƒ
Ó
ô
ú
îXwt–®æ48B¨‚¼ÃFI‚¦l¶ÎÓû$knÙô›Ì"4}©i½0þy¾!°!%  æ 8¶ð½)
dÏ5�oKS�(1ÊÏ†mÎít”_¦aý" < }!6  r¦‡Ì÷ .	°	Ñ	ý	
?XˆÂÙG�AFÂÎæo¬ 19a’™BXA€†•¥¸;ESÒÅ_cC!�!˜!H å ì |ÁÈãAµÀÇ;º¹óJo§Ïñõ¢	¬	`
‚
Î
ó
ù
cíŽ—
7ËE�Ž¥³Òèú#CjÎÞaý…”Ÿ´Øl°Íh¼ã½~�—¥ª!|!w ¤¥àáâ†´¿
IlmnÎü	�
ò
÷
ø
>VW‡�¿ÀÁØ	EFvwxy@EDåÑæçþÿ078=>?@ABÍ_`fgˆ˜úûü:?@A‚ƒ„ž…”¤®¯Ìl0fg›ÀÁ89:DQR¾ÐâÏÐÑ£¤ÃÄé$%&'}~A!B!z!{!Œ!—!# › "ãPÊýfz”°ùh‰;¨Ïm†1…œÂ"¿Ñê(&!§! ?“	‚SþÍ&iŠ$�Àëb '!( � ä[EQW\bzÔã.vÇÍhù}
9Õg{p˜À©Ð�‡2ÎúŸ‘Í0 yµ#ê8Xz)³¶XBËR
¼
'pÛAÃ„™ðA•±úW<n†Ãê0ª )­°¤!»! œ ó Ãdó9¢Q<#3KÒk¯ï€µ ý ƒ!¨! F“Æ˜ÈIajF	m
ƒT¨^w™éq}×FÐýž¶¨Q â !! @^Î°(ú W_	¦	­
Ä5Gw¼è'-»á:s¬qŽÝ™=! ú Ïêßî-Èá.Gÿ±sY¢V+R‹%ÉÖXöì c M!# " e‡7P¤t†îôt”	™
|7äŒÎN$wjú6*Á!íãKì(! A LŠ‡RX]c{ÈŠ	í
:r [ÿ ž)�3+tû’P!$ ªpŸÛV\€£ú†
}ÀžþžÉq™É=ž¹ÁÙÑé*UÏû¥lÎ0 $ ‚ Ó ÍåF/~
	Q™¨½#~›«¶^…Ÿn5_ª‘9vßäëƒ Ï( Ï Œ�Õä2wÂÎ]i¢
e†‘PhÖÜ_h|él­:žˆ3<XIP\�!  öQY{w·X	
Sk¹§e°ñ–F{§¬ðë«¡Ì*5Öð0!¼! W¶$ë��ÛS
½
(qÜB÷Ä…šÞ;²”ûXÄe´±& zÞ ²9V$*±´YCoÌT¬b$¦ˆBÜ÷=‡]{®  !¥! m JOurþU·LW\Ü;oœ£1áÍ ô 3Œ	%
y
9®ýÚ$°�Ñ  £bØüD–&*ú‡¢”(ÊHÓðþ  TLçYû
%6k	�Äãe:£¼NRqL´À!ø!„!©! o � ^¤:£±.öôy¾	=õ4lÛ¶ ³! « N$‰ÀJbn,
n
áxLrÂ•ØèŸ$& R [ "! Q É7	s	>
šŸÙê;�³}KÕ&=p­b·‹h@ Ç ã Y!  GvàÇ™Ñè„U”©„Ûž¤Èð«g�¬ùÔæYN Ó €! ö ”˜§ÀkèG	_o~–Ø÷$GˆÌÑþø?žo©²Ú u!" 4 = I AÏhfqŽXz	§	 
Ê
5é£#ÍHTÒçŒÈé¼Ü	tIŒô   , ;¯/ò)ª¹=	�½ò.âh¢
G$W@NšÇ¿Y>ƒ{ ‰ ¹   ~ ÒAbª±ÜÛûl¿K	`	ÅP6Èû;Ô­¹�Ôß3³+ 6 >! 0 ”   _j“	K
®
uîñx“Sã(r�ÞÇ! # ½ah™¹ó…	Éö/`Z²4t÷W,&{íM×Y&!Ûã d œ )  û ú’k¦¬Ðz‰à�	u
µ
Ã
 .wÔâH h‰ «#ã5Säï00¼ w ¸ë@ï,	É	'
{
Í3û	£±–³"ÊëÎ÷Cí®!& …Š5¡ÙW„Æù#¡i	,ô3oºDJqÚæZ�ÇçŒûFÇÔ7Žù;!N!; s u fh�ƒˆ-—¡ª¥‡5æ*	•	—	œ	Û	š
œ
±
³
’�ß}ô8•ì)km�œÝÿ2�°úÒ ùÞEG«÷ä.s!( & 8 b ¶ » Ø¨!-NÝ	
8
ž
ÓÝK®ß·ü³xÒ
.IwŽ´%H›I ð   b8T«Ì•7Õ'1%àAkØÿÜcÌ¥LPí² C 
 # Y i Q£Tu�Ø ¹ïõux	™	ž	Æ	W
Ÿ¼ö(:�—�¨«àå$+@™°ÏOn’ž²àû7^Îà`+Â"îà­ 
!)!j! — à #	SY°¶Id‘ œ¦±·ïúZ*‘—,Ë Ý è  !Q! ‹¥¯2ˆç		 ´«,°õ*]4SýGuü–� B ¯ M€ä{C	;PKb^!/ÿ\ÕâCŸ€Mn~  + ( : ‹ *‘Òþ^|§õTÉ‹	î
s¿ÕFfrk>nP!KÁ©ñV“K l q ™ m! Ü/v»	ï	Z
g~8Ó[�)_boh	zmÏ1 > d «Ú ]ö]Ò…û$		

N
‘
¥
á
 H‘°µüfËò,PNbk–ÿµÊèrzëN[dŒñšŸÂvÁV¶ÐJÖ@D¤ ] ½ œq(=‘¤Å	B
‡
ÁWŸÊìŠ¡¤çüÕ7u2 ¸ ÖWÙ7:�ˆ˜ã¸	r
»ßMz‰Œ’¤°¹ŸÛ>ºÚÒê+JeÑò@Ñ¦¢°Ø=@r0wp!$ 3ªæÉ1¬/›ã	0
Û
æ
k}á¬·’ÞÃÔ6#wài�ÛåÐ ! ÎH	´	š©£çëü_;TzTÌ`�¶'‡„æ" ƒ Ô w?M‚ÂCG»R	‘	ú	

<”t‚ë2†€’Ì Bìh¡# H0S	 
«
ë
OR¾	!$pi E{]œ8† ýTo«yû:—[' ’ �dÚ
"Ö3xÏj½x	<
ÒÓÝf‡!›Ù'i®Þ±;Š)° ò # !��š0×ß	á	ø	:
£
8:’\x.C`iÁê„m®óŸ‰QÖh j ž! Ð é €{=^Á	(Æ2}t�À™˜ß+™�ô]òÊ$ Û Få~Ã#Pf	µ¸è0Q!AW×Ýþ0‹ÊÔ4=YJ&MÇÝ† ,!  Ž £ �“Tº¨ú<f¥±÷ÂÜçežU€µ¹ÍöŒ!†!‘!   ‚|}“‹Y	*™—›SOa­Úäïx¬ÄN_ôV � 1!·! :
ƒÆl´ò+ã(CG½|N1qª×ú!½!# ÷RZx%Ô¸ý­Ž	Ã	ì	ÈXü84%¨ñ ìƒ›¢+69ñ 
 «! XêœÜž4
†âüYfµ² %!²ÜÎqÎß<ŸÆÅÇô -·�9	=›³•vcµï-N3¢ _! ì‚­T
Ž
¾
)rÝCø4Å¾P]Rsãƒ – * m”Vll%++=jè?Z�½&8D`p„m	ƒ3‰u¥.»þì¶<ñ<t 5! ïûvs­å3A§R~'0Í�õsˆ/^¥`Þ! ,  ä ë {ß!³¾:¸òÍ¡	
ñ
Ub¾×DC�Á"Ýø^>š7áÎŒÂ#|!y!‹!–!¦!& ò WZ([ay²µâWuÆÌÂc¡ÂÔ%˜�;ùJ©jŸ®ž�¯Ì´ ü ' ! ù EdÅÎés—'HÞíóùÿV,àF§ã
vMÏ,àX«Wì§âëL! Î Ò KÌ¼}gš]<m^kT�ÞW¤2H[‚Î/ œ! l VNPUv€Úö¸aVÝ:›«dzÕï/! n ]×C£95°)âùx­½'»Mpô
 õ M—nžØƒ:²ö#|”×ª÷ n±Óg% ? Ò ! + 3 } Ÿ p�Ú	J	J
ÌSÑæR‹âñÇg¸€Þ2Æ?Æ¾‚ˆ ¸ %  4`¥VƒÅø"ˆh	È	&
z
Â
võ_+ÿ2CpÙö4EÆ6%»1 	  % h r S–ªS¸w	›	Ò0J§ª­ë#?›Üþ1�¯¶ßù²-�³Í×þÛ$ËOß ß ¤ýH¦¥zO¾ùY).máÀ\LüU   p ÿ l! \ Õ—â
Y
º+ˆ‘£(•çê‹‰ÀIdñ?ÐÔ¡yÕv£ v0«RÚ
¢æûŸêSË†Œ ™/cÖÙ	E<'´·7šØç&-B­@VŒ(œñLÆÉ¯ +! ü‚Å³;¤ û7˜ö$æN`ãîM0ù!!…!ª!¶! é›±�
<½Ob´â‚ • ^!&  *Zixç€¼Å%7l	 	
Crä ÁQŒ]ý:r.6Iµð­ÁÝ"x!Š!•!# k UMÄè¢&GÝìòøÙ¯øâ	f¬¼+9ª]jSV	Zê.!% q ž L_I
Á
u*/Iê"Ûõ0Q{œµðÆÖÝ,ÅÌÖöÅm·  [ Þ ¥ª;¤¡³å™×ø'‹ð>[o  èÃwF»Üëñ÷°ØÀP8iå9â³í-5¬Üµ! p Ý ²÷!z´¿ÕO7Š
Ä²Ä ´!  1Ð  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                         %                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   %                
                                                                                     	                                                          	                           
   
      
               4            
                              
      
   
                        #         	                  
   	         ;   1   '      %   <      "   )      $   ‚   ‚   #   0   (   #      1   w                                                                                                                                                                    %                                                                                                                                                                                                                                                                                                                                                                               %      
                             	                    	         
 
  
     4    
          
  
 
        #   	      
 	   ; 1 '  % <  " )  $ ‚ ‚ # 0 ( #  1 w   ‰  ŠP  Šx  Š²  �œ  ”ì  �HFæ3!™H¦Hšþr ™èHƒ¦Å¥ÜÝR¡³Û#Yzû»Ò x!Š!š"�ÚÊff ïiË¡jMÆ ~G!¯šM«‡••g < YòÊ}	,fýZ�û Z ® Ú €¢ÂÍç¯�	–	î	)2ÖlšÇù&ŠýZ/MV]�«/k!0)OŠ›;šÕ?"Š›óš?Ø"Š›š?"Š›ŠŠŠ›Š�Ú1Ö ‡&7�!^›Ëgæ/xI0Y}	,07Ÿ¦;ù•l›ü7ji°;–ÀüÊ›ÃTS ÀNš;GÿeÂR¤'Š´Š‡z»"ø££ú
BÃÓŸŸòä›Œ]"y9
GFúHDÙ H&—˜ì\V Û4	IíÉÌAz –”§-P	G	ãû=ˆÃž<ýO
¹
$mØ>c>~-g‘¥x[ayÆ�Ÿº&ò—Hä›\Œ
¼©)	ÑY°ìøLŸ!©»BZuÝ–‡Üe –‡e LHVÖâÃ„ ¿ S	�xw›3
â™íÃ–‡e –-=QBZâs-ÃÝ¯Ã9dx	!Šò W&—\_°/
v
×Î 8	‡	›’Ûõ­ýü1×– W “&—l\« !Ù HQÁ„´F
â&—ñ,7˜ìÂÃòL\®üÏøVZ!�!¥Í'¥¶5!/ Å3³ß¨·ñ�
xƒ	ÒXf‡Þ LM›Ä«G€¤¼Y
Øøù›(Yz”ÕÖåÿ ß
B�	��9©ÿ> Ñ 62ì–m‚"©Ò€ –	›
�H{	”§G	ˆ¥o Ïx0 “”§G	Åˆ3³N ¦�	‰ ãJZJ«BZâs-u™íÃÝ–‡Üe (ïvßÏŸ!"y›«€¼Y
(UaS Å%  � ª c€g– ~–	/
3
›
Üàm½HÚù/�›Ûl6#+¿´;k!�!«Ø›2â	/
Â"Ÿ!Q‰o! ±±½a® ãJ}Á	Æ}™LÖ›Áo—Ëè”Ÿ´°ã—ªÓ‰Å W!	BZÝ¤Õ¥xÍ[ayÆ'�“%6 <¹
$mØ>Q�]U2µ¸]Ua2Ó{g¾	"Wy­Ù'îðk–‡}e � W£$�þUi¦	±9§°s+ÖXvßÌÏlÎ0 ¶ =©)	ø–‡¢HÇ) á –m‹ ‹	›×©VK oÐåŠÏ§Výü‹ ‹	]V¥¶/ 5!éÆá} úÄ51 Ê¶¼Y„½	îÏ,í(ï Dç‰H¹W�Qo³› á±iRŠ7È²¾ß H¥ù;Y¤ )öæÿ !…!t¶K[à¨­Jã' 9 Š Ñ$ô�	ë	ÔWj=J‚ð8 	 J ÁfÂµÚé#
F
âã›…ü<ªÙ%öÃÄL*S»™ªùLMõ{”Ö×öm% rõ1	gÕ¸äÂPÖÜ3<XI#
F
›…<ªöL»™' 9 Š ÑôÔj=JðJ $�	ë	W‚8 	 RŸÝ7udƒÿ•¤U‚Ä÷!‡Ç	ô^þoDÅº$ ' 9 Š RÑ$¦©¿Rô·çv�	š	ë	Ô©¬Wšýj‡Ë=J²>#‚�ð8 	 J Ù t!ß LMH¥ùõ;Y{”¤ Ö×)öæöm% ÿ !…!Ÿ
h\SxúZ”àc¯t,H!¢ Œ’ÁÛ�Tõ‹zO.áL   ež“c‚7	$ ûK�2Y	SNô� ˜¢-õ  ÐB	g	]Ú1BØõ *â3¼ÔB5mp©!KY	qS�ˆ2Nô� B ¯ €ä{K/~  €{Á	(Æ}À™ô]ò`¦¯
ºÛò÷Ü
„‰~n¹IÆúø:!q /Iê"Û0œµ,ÌÖª ˆmàKÁ>  [³0œx!r¡–º{Ž(- ¹!_…5„Æ®
îñ3o“ºDqãæŒûÇÔ!;!{Š‡ŒÈX	™éÿ–¬)3«¶tû�â 0!ZxÅ Á:I­N«óÀ„º ‹~ºÁ\×	(
Î4d…³nOÛJè9Øì“Oè"mˆü; S °™±Å)Žº_%zÈ»V±´b$®> [œr¡–(º{- ‹~ºÁ\d…³OÛè9ØO" ³0x!Ž¹!$ R¦©¿R·çvš	©¬šý‡Ë²>#�Ù t!B ¯ €€{ä{Á	(ÆK}/À~™ô]ò  ÊÝï0œîŒ
9� äE.}
©�Ÿr	=
J%<oa3%
y
$s u fh�ƒˆ-—¡ª¥‡5æ*	•	—	œ	Û	š
œ
±
³
’�ß}ô8•ì)km�œÝÿ2�°úÒ ùÞEG«÷ä.s!	  % h r S–ªS¸w	›	Ò0J§ª­ë#?›Üþ1�¯¶ßù²-�³Í×þÛ$ËOßP ª uß¦¿ˆmçç6	“àKŽ�£ÁÇï‡ËÔf€¬>«ø�ŠåXM Æ Ù X!t!IÆ§ÑŽ{Š‚	¾	
ïWŠÐ§#ú	$-îä)ð¡E Œ Ì +C’[j¶#ÿ_UÊŒ	ê	ï
tÀV?Þo¹Ä¹Åhqr   ú 7 X t µ g€‚×, ¢Ë”6 ,M–	˜	�	Å	Ü	
7
›
�
²
žõ'9–ß*l˜Þ m�‘±ûÑH]ßFªöG¤-šH ¬ ï XêœÜž4
†âüYfµ²R�Š‘›pümˆ	Æ,Q7Õ"´üœÈœ4}¡²´âôI²¾j{ —•™¨Á.Qg Ã¶Úé
H	­ãlpýÙäü%>‰Ä,Ä*TŸªúÄv!ˆ!“!õ M—nžØƒ:²ö#|”×ª÷ n±Óg% ? Ò 3ªæÉ1¬/›ã	0
Û
æ
k}á¬·’ÞÃÔ6#wài�ÛåÐ ! ) { Œ Ì â ÷ +C’—[jÓn•™¶#‘¨Áÿ&.Q_g ¨ÃöDU†¶ÊÚé
H	Œ	ê	
Ø
ï
óM]t­ãlpÀÖG�ÕýVtÙäøü%.>‰ÍÒ?ÄÞ,koQ–¹Ä"[¹Ä*L¾ÂêTŸÅhª³·ÑúqŽ¹Ä T m r   ú \!v!ˆ!“!î ý .3¸ŽªÎÙæ %'H¼ÉLŽ˜1¬/›©Ô		´	ã	0
Ô
Û
æ
û
š¡©ïYkx£çë#ü>}áC¬·_az½Ä;JLTƒ’§z…§·»ÔÞ%Tuƒ°ÃÔï7Ìæèö6`5ª�’¶#jwÔàð'iz‡�Ûå4„†ˆÐæ£ !`! !¼¸ò‘ Øy? „	t
ÓúYgˆóåœ"âæ²/zìLÓ�ÍBâ‰ 	=[Ðyâ&A ¹þ†"	�	²	å	í	ß
®údÄÉÛINY<€ý9RYbt —!ˆ|Ô•ï>f ¾ 	=ÿÖþ>¥ýP
º
%nÙ?Âdä?ªÈ.\hœËÄ’¦ÅÊ {¢wv¨k UMÄè¢&GÝìòøÙ¯øâ	f¬¼+9ª]jSV	Zê.!J duÃ4?g_hóžËHY[	{	!
$„ê½‘(,¹‡õ … À ÂäÁÈº3p	T	a
˜ÀÄÌæÁéDŽžßµÐþ• µÇÙå%y±ö»päQxc˜¦«ß Œ ˜ Ì +C’¼Ë[¸òj‘ ÄØ
)@¶#T`i~·ôÿJ_æUyÄÊ$?Z \	„	Œ	ê	
"
t
Œ
ï
ÓtúBYgˆÀ²óVƒ«»åëÿ*?Þoúm‹œ¹"Ä©âæ²/\zìL¹Ó-m�’ÍÅBhU·âq†ér � ”   Ì ú -!@^Î°(ú W_	¦	­
Ä5Gw¼è'-»á:s¬qŽÝ™=!   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  "L<?xml version="1.0"?><Features nextValidID="16"><Feature recentID="0" name="piggyBac right (3') inverted repeat" type="repeat_region" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" originalSequence="CCCTAGAAAGATAATCATATTGTGACGTACGTTAAAGATAATCATGCGTAAAATTGACGCATG"><Segment range="5572-5634" color="#ffcc99" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;!--StartFragment--&gt;piggyBac transposon-specific inverted terminal repeat sequence (ITR)&lt;!--EndFragment--&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="piggyBac left (5') inverted repeat" type="repeat_region" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" originalSequence="CCCTAGAAAGATAGTCTGCGTAAAATTGACGCATG"><Segment range="489-523" color="#ffcc99" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;piggyBac transposon-specific inverted terminal repeat sequence (ITR)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6828-6932" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="AmpR" directionality="1" translationMW="31558.16" type="CDS" allowSegmentOverlaps="0" cleavageArrows="7001" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment name="signal sequence" range="6933-7001" color="#ccffcc" type="standard" translated="1"/><Segment range="7002-7793" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="4" name="PuroR" directionality="1" translationMW="21497.23" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3785-4384" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;pac&lt;/i&gt; from &lt;i&gt;Streptomyces alboniger&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to puromycin&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;puromycin &lt;i&gt;N&lt;/i&gt;-acetyltransferase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MTEYKPTVRLATRDDVPRAVRTLAAAFADYPATRHTVDPDRHIERVTELQELFLTRVGLDIGKVWVADDGAAVAVWTTPESVEAGAVFAEIGPRMAELSGSRLAAQQQMEGLLAPHRPKEPAWFLATVGVSPDHQGKGLGSAVVLPGVEAAERAGVPAFLETSAPRNLPFYERLGFTVTADVEVPEGPRTWCMTRKPGA*"/></Q></Feature><Feature recentID="5" name="lac promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-35" range="230-235" color="#ffffff" type="standard"/><Segment range="236-253" color="#ffffff" type="standard"/><Segment name="-10" range="254-260" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="CAP binding site" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="194-215" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="lac operator" type="protein_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="268-284" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7964-8552" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="hr5 enhancer" type="enhancer" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2740-3222" color="#a6acb3" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Autographa californica hr5&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;baculovirus early transcription enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="IE1 promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2145-2736" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter of the &lt;i&gt;ie1&lt;/i&gt; gene from the baculovirus &lt;i&gt;Autographa californica&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="DsRed1" directionality="2" translationMW="26030.24" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="0" hitsStopCodon="1"><Segment range="1454-2128" color="#ff0000" type="standard" translated="1" translationNumberingStartsFrom="2"/><Segment name="1a" range="2129-2131" color="#ff0000" type="standard" translated="1" translationNumberingStartsFrom="0"/><Segment range="2132-2134" color="#ff0000" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;mammalian codon-optimized&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;wild-type DsRed&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="M,V,RSSKNVIKEFMRFKVRMEGTVNGHEFEIEGEGEGRPYEGHNTVKLKVTKGGPLPFAWDILSPQFQYGSKVYVKHPADIPDYKKLSFPEGFKWERVMNFEDGGVVTVTQDSSLQDGCFIYKVKFIGVNFPSDGPVMQKKTMGWEASTERLYPRDGVLKGEIHKALKLKDGGHYLVEFKSIYMAKKPVQLPGYYYVDSKLDITSHNEDYTIVEQYERTEGRHHLFL*"/></Q></Feature><Feature recentID="12" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4402-4536" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="SV40 poly(A) signal" type="polyA_signal" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1212-1333" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="M13 fwd" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6338-6354" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="M13 rev" directionality="1" type="primer_bind" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="292-308" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
  È<?xml version="1.0"?><Primers nextValidID="15"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/><Primer recentID="0" name="Amp-R" sequence="ATAATACCGCGCCACATAGC" description="Ampicillin resistance gene, reverse primer"><BindingSite location="7150-7169" boundStrand="1" annealedBases="ATAATACCGCGCCACATAGC" meltingTemperature="58"><Component hybridizedRange="7150-7169" bases="ATAATACCGCGCCACATAGC"/></BindingSite><BindingSite simplified="1" location="7150-7169" boundStrand="1" annealedBases="ATAATACCGCGCCACATAGC" meltingTemperature="58"><Component hybridizedRange="7150-7169" bases="ATAATACCGCGCCACATAGC"/></BindingSite></Primer><Primer recentID="1" name="DsRed1-C" sequence="AGCTGGACATCACCTCCCACAACG" description="DsRed1, forward primer"><BindingSite location="1515-1538" boundStrand="1" annealedBases="AGCTGGACATCACCTCCCACAACG" meltingTemperature="65"><Component hybridizedRange="1515-1538" bases="AGCTGGACATCACCTCCCACAACG"/></BindingSite><BindingSite simplified="1" location="1515-1538" boundStrand="1" annealedBases="AGCTGGACATCACCTCCCACAACG" meltingTemperature="65"><Component hybridizedRange="1515-1538" bases="AGCTGGACATCACCTCCCACAACG"/></BindingSite></Primer><Primer recentID="2" name="DsRed1-N" sequence="GTACTGGAACTGGGGGGACAG" description="DsRed1, reverse primer"><BindingSite location="1930-1950" boundStrand="0" annealedBases="GTACTGGAACTGGGGGGACAG" meltingTemperature="60"><Component hybridizedRange="1930-1950" bases="GTACTGGAACTGGGGGGACAG"/></BindingSite><BindingSite simplified="1" location="1930-1950" boundStrand="0" annealedBases="GTACTGGAACTGGGGGGACAG" meltingTemperature="60"><Component hybridizedRange="1930-1950" bases="GTACTGGAACTGGGGGGACAG"/></BindingSite></Primer><Primer recentID="3" name="L4440" sequence="AGCGAGTCAGTGAGCGAG" description="L4440 vector, forward primer"><BindingSite location="59-76" boundStrand="0" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="59-76" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite><BindingSite simplified="1" location="59-76" boundStrand="0" annealedBases="AGCGAGTCAGTGAGCGAG" meltingTemperature="58"><Component hybridizedRange="59-76" bases="AGCGAGTCAGTGAGCGAG"/></BindingSite></Primer><Primer recentID="4" name="M13 Forward" sequence="TGTAAAACGACGGCCAGT" description="In lacZ gene. Also called M13-F20 or M13 (-21) Forward"><BindingSite location="6337-6354" boundStrand="1" annealedBases="TGTAAAACGACGGCCAGT" meltingTemperature="57"><Component hybridizedRange="6337-6354" bases="TGTAAAACGACGGCCAGT"/></BindingSite><BindingSite simplified="1" location="6337-6354" boundStrand="1" annealedBases="TGTAAAACGACGGCCAGT" meltingTemperature="57"><Component hybridizedRange="6337-6354" bases="TGTAAAACGACGGCCAGT"/></BindingSite></Primer><Primer recentID="5" name="M13 Reverse" sequence="CAGGAAACAGCTATGAC" description="In lacZ gene. Also called M13-rev"><BindingSite location="291-307" boundStrand="0" annealedBases="CAGGAAACAGCTATGAC" meltingTemperature="49"><Component hybridizedRange="291-307" bases="CAGGAAACAGCTATGAC"/></BindingSite><BindingSite simplified="1" location="291-307" boundStrand="0" annealedBases="CAGGAAACAGCTATGAC" meltingTemperature="49"><Component hybridizedRange="291-307" bases="CAGGAAACAGCTATGAC"/></BindingSite></Primer><Primer recentID="6" name="M13/pUC Forward" sequence="CCCAGTCACGACGTTGTAAAACG" description="In lacZ gene"><BindingSite location="6346-6368" boundStrand="1" annealedBases="CCCAGTCACGACGTTGTAAAACG" meltingTemperature="61"><Component hybridizedRange="6346-6368" bases="CCCAGTCACGACGTTGTAAAACG"/></BindingSite><BindingSite simplified="1" location="6346-6368" boundStrand="1" annealedBases="CCCAGTCACGACGTTGTAAAACG" meltingTemperature="61"><Component hybridizedRange="6346-6368" bases="CCCAGTCACGACGTTGTAAAACG"/></BindingSite></Primer><Primer recentID="7" name="M13/pUC Reverse" sequence="AGCGGATAACAATTTCACACAGG" description="In lacZ gene"><BindingSite location="272-294" boundStrand="0" annealedBases="AGCGGATAACAATTTCACACAGG" meltingTemperature="58"><Component hybridizedRange="272-294" bases="AGCGGATAACAATTTCACACAGG"/></BindingSite><BindingSite simplified="1" location="272-294" boundStrand="0" annealedBases="AGCGGATAACAATTTCACACAGG" meltingTemperature="58"><Component hybridizedRange="272-294" bases="AGCGGATAACAATTTCACACAGG"/></BindingSite></Primer><Primer recentID="8" name="mCherry-F" sequence="CCCCGTAATGCAGAAGAAGA" description="mCherry, forward primer"><BindingSite location="1713-1732" boundStrand="1" annealedBases="CCCCGTAATGCAGAAGAAGA" meltingTemperature="54"><Component hybridizedRange="1713-1732" bases="CCCCGTAATGCAGAAGAAGA"/></BindingSite><BindingSite simplified="1" location="1713-1732" boundStrand="1" annealedBases="CCCCGTAATGCAGAAGAAGA" meltingTemperature="54"><Component hybridizedRange="1713-1732" bases="CCCCGTAATGCAGAAGAAGA"/></BindingSite></Primer><Primer recentID="9" name="pBR322ori-F" sequence="GGGAAACGCCTGGTATCTTT" description="pBR322 origin, forward primer"><BindingSite location="8452-8471" boundStrand="0" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="8452-8471" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite><BindingSite simplified="1" location="8452-8471" boundStrand="0" annealedBases="GGGAAACGCCTGGTATCTTT" meltingTemperature="56"><Component hybridizedRange="8452-8471" bases="GGGAAACGCCTGGTATCTTT"/></BindingSite></Primer><Primer recentID="10" name="pBRforEco" sequence="AATAGGCGTATCACGAGGC" description="pBR322 vectors, upsteam of EcoRI site, forward primer"><BindingSite location="6741-6759" boundStrand="1" annealedBases="AATAGGCGTATCACGAGGC" meltingTemperature="57"><Component hybridizedRange="6741-6759" bases="AATAGGCGTATCACGAGGC"/></BindingSite><BindingSite simplified="1" location="6741-6759" boundStrand="1" annealedBases="AATAGGCGTATCACGAGGC" meltingTemperature="57"><Component hybridizedRange="6741-6759" bases="AATAGGCGTATCACGAGGC"/></BindingSite></Primer><Primer recentID="11" name="pGEX 3'" sequence="CCGGGAGCTGCATGTGTCAGAGG" description="pGEX vectors, reverse primer"><BindingSite location="6681-6703" boundStrand="0" annealedBases="CCGGGAGCTGCATGTGTCAGAGG" meltingTemperature="66"><Component hybridizedRange="6681-6703" bases="CCGGGAGCTGCATGTGTCAGAGG"/></BindingSite><BindingSite simplified="1" location="6681-6703" boundStrand="0" annealedBases="CCGGGAGCTGCATGTGTCAGAGG" meltingTemperature="66"><Component hybridizedRange="6681-6703" bases="CCGGGAGCTGCATGTGTCAGAGG"/></BindingSite></Primer><Primer recentID="12" name="pRS-marker" sequence="CGGCATCAGAGCAGATTGTA" description="pRS vectors, use to sequence yeast selectable marker"><BindingSite location="6562-6581" boundStrand="1" annealedBases="CGGCATCAGAGCAGATTGTA" meltingTemperature="54"><Component hybridizedRange="6562-6581" bases="CGGCATCAGAGCAGATTGTA"/></BindingSite><BindingSite simplified="1" location="6562-6581" boundStrand="1" annealedBases="CGGCATCAGAGCAGATTGTA" meltingTemperature="54"><Component hybridizedRange="6562-6581" bases="CGGCATCAGAGCAGATTGTA"/></BindingSite></Primer><Primer recentID="13" name="Puro-F" sequence="GCAACCTCCCCTTCTACGAGC" description="Puromycin resistance gene, forward primer"><BindingSite location="4280-4300" boundStrand="0" annealedBases="GCAACCTCCCCTTCTACGAGC" meltingTemperature="60"><Component hybridizedRange="4280-4300" bases="GCAACCTCCCCTTCTACGAGC"/></BindingSite><BindingSite simplified="1" location="4280-4300" boundStrand="0" annealedBases="GCAACCTCCCCTTCTACGAGC" meltingTemperature="60"><Component hybridizedRange="4280-4300" bases="GCAACCTCCCCTTCTACGAGC"/></BindingSite></Primer><Primer recentID="14" name="Puro-R" sequence="GTGGGCTTGTACTCGGTCAT" description="Puromycin resistance gene, reverse primer. Also called puro-variant-R"><BindingSite location="3784-3803" boundStrand="1" annealedBases="GTGGGCTTGTACTCGGTCAT" meltingTemperature="59"><Component hybridizedRange="3784-3803" bases="GTGGGCTTGTACTCGGTCAT"/></BindingSite><BindingSite simplified="1" location="3784-3803" boundStrand="1" annealedBases="GTGGGCTTGTACTCGGTCAT" meltingTemperature="59"><Component hybridizedRange="3784-3803" bases="GTGGGCTTGTACTCGGTCAT"/></BindingSite></Primer></Primers>
  P<Notes>
<UUID>ed9716c2-f2b2-4081-a2a7-480d42e9c0ce</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>Opie2-PuroR</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Description>Expresses PuroR and dsRed..</Description>
<Created UTC="23:32:18">2021.5.12</Created>
<LastModified UTC="23:32:18">2021.5.12</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
<References>
<Reference authors="Kandul NP, Liu J, Hsu AD, Hay BA, Akbari OS" type="Journal Article" pages=" 10.1038/s41467-020-16020-2" title="A drug-inducible sex-separation technique for insects." journalName="Nat Commun." journal="Nat Commun. 2020 Apr 30;11(1):2106. doi: 10.1038/s41467-020-16020-2." volume="11(1):2106. doi" date="2020-04-30" pubMedID="32355156"/>
</References>
</Notes>
  Y     –         
?????                                                                                                       ÿ d      HO  d               E              ÿÿÿÿYô? P                                                                                                                                                              3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
